Green-Synthesized Zinc Oxide Nanoparticles From Indigenous Medicinal Plants for Multidrug-Resistant Bacterial Infections
DOI:
https://doi.org/10.61919/xwn32y37Keywords:
Azadirachta indica; Antimicrobial Resistance; Multidrug-Resistant Bacteria; Mupirocin; Nanoparticles; Wound Healing; Zinc OxideAbstract
Background: When we get infections from bacteria that're resistant to many medicines it is really hard to treat them with the usual medicines. This is why we need to find ways to treat these infections. We think that tiny particles of zinc oxide that are made in a way could help to fight bacteria and heal wounds. Objective: We wanted to see how well a special cream made with these zinc oxide particles worked compared to another medicine called mupirocin. We used this cream on people with skin infections that were resistant to medicines. We also wanted to see if the size of the particles made a difference in how well they fought the bacteria. Methods: We did a study in Karachi, Pakistan from May 2025 to January 2026. We had 84 people in the study. We divided them into two groups. One group used the cream with zinc oxide particles and the other group used mupirocin. They used these medicines twice a day for four weeks. We looked at how many bacteria were on the skin how big the wound. If the wound was completely healed. Results: After four weeks we found that the people who used the cream with zinc oxide particles had bacteria on their skin. The wounds of the people who used the cream with zinc oxide particles were also more likely to be healed. We found that the smaller the zinc oxide particles were, the better they were at killing the bacteria. Our study showed that the cream made with zinc oxide particles worked better than mupirocin at fighting bacteria and healing wounds. This is a sign and we think that we should do more studies, with more people to see if this cream really works
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Copyright (c) 2026 Ayesha Zubair, Mohammad Shaiq Mahmood, Aqsa Ashraf, Taiba Ahmad, Raja Kamran Afzal (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
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