Neuromodulatory Impact of Low-Intensity Focused Ultrasound on Early Cognitive Decline
DOI:
https://doi.org/10.61919/pfm2z844Keywords:
Attention; Cognitive Dysfunction; Double-Blind Method; Functional Connectivity; Memory; Mild Neurocognitive Disorder; Non-Invasive Brain Stimulation; Randomized Controlled Trial; Ultrasonic Waves.Abstract
Background: A mild neurocognitive disorder causes problems with memory, attention and thinking skills.. There are not many good ways to treat this that do not need surgery. Objective: To see how active low-intensity focused ultrasound and fake ultrasound affect memory, attention and brain connections in people with neurocognitive disorder. Methods: This study had 76 people, aged 55 to 80. They were split into two groups. One group got ultrasound that targeted parts of the brain related to thinking and memory. The other group got a treatment. They tested the brain functions of the people before the treatment one week after and two months after. Sixty-eight people finished the study. Results: One week after the treatment people who got ultrasound had better memory than those who got the fake treatment. The difference was still there two months later. People who got ultrasound also did better on a test of attention. Their brain connections between the part of the brain and the hippocampus were stronger, than those who got the fake treatment. No serious problems happened. low-intensity focused ultrasound seems to help with memory and attention and makes brain connections stronger.. More studies are needed to be sure
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Copyright (c) 2026 Abdul Rehman Naeem, Mahwish Haque, Saima Kanwal Attique, Maqsooda Akram Butt, Syeda Qaima Abbas, Sameea Areeb (Author)
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